Biology Chronic Kidney Disease Paper

Want create site? With you can do it easy.

Biology Chronic Kidney Disease Paper

Chronic kidney disease is a gradual loss of kidney function. you will explore this disease in more detail using the scenario below.Scenario:

Don't use plagiarized sources. Get Your Custom Essay on
Biology Chronic Kidney Disease Paper
Just from $13/Page
Order Essay

Your parent has recently been diagnosed with chronic kidney disease. Your parent is confused about what this means and asks you to help them navigate their care. You decide to research the disease to help support your parent..To complete this , do the following:1. Research this disease using a minimum of 2 source(s). You can use your textbook for one of the sources. Choose the remaining sources from the GALE Virtual Reference Library provided on the.2 address the following:Explain how chronic kidney disease develops and the potential causes.Describe the treatment options that exist.

research sourcesDavidson, Tish. “Kidney Disease.” The Gale Encyclopedia of Medicine, edited by Jacqueline L. Longe, 5th ed., vol. 5, Gale, 2015, pp. 2851-2853.Davidson, Tish. “Kidney Disease.” The Gale Encyclopedia of Medicine, edited by Laurie J. Fundukian, 4th ed., vol. 3, Gale, 2011,pp. 2475-2478.Woldin, Barbara. “End-Stage Renal Disease.” Magill’s Medical Guide, edited by Bryan C. Auday, et al., 7th ed., vol. 2, Salem Press, 2014, pp. 749-751.

The kidney is a complex organ responsible for maintaining multiple aspects of homeostasis in the human body. The combination of distinct, yet interrelated, molecular functions across different cell types make the delineation of factors associated with loss or decline in kidney function challenging. Consequently, there has been a paucity of new diagnostic markers and treatment options becoming available to clinicians and patients in managing kidney diseases. A systems biology approach to understanding the kidney leverages recent advances in computational technology and methods to integrate diverse sets of data. It has the potential to unravel the interplay of multiple genes, proteins, and molecular mechanisms that drive key functions in kidney health and disease. The emergence of large, detailed, multilevel biologic and clinical data from national databases, cohort studies, and trials now provide the critical pieces needed for meaningful application of systems biology approaches in nephrology. The purpose of this review is to provide an overview of the current state in the evolution of the field. Recent successes of systems biology to identify targeted therapies linked to mechanistic biomarkers in the kidney are described to emphasize the relevance to clinical care and the outlook for improving outcomes for patients with kidney diseases.

Biology Chronic Kidney Disease Paper

Biology Chronic Kidney Disease Paper

Why Is a Systems Approach Needed to Tackle Kidney Diseases?
The kidney plays a central role in maintaining homeostasis in the human body. To successfully carry out these functions, the kidney contains numerous cell types arranged in the complex three-dimensional structure of the nephron to respond to a variety of hormonal, neuronal, inflammatory, and intra- and intercellular signals. The network of complex, intertwined regulatory functions across different cell types make the delineation of specific mechanism associated with loss or decline in kidney function challenging. Clinical trials for the development of diagnostic markers and novel therapies targeting kidney diseases have consequently been limited (1–⇓3), resulting in few prevention and treatment options available to clinicians and patients.

Much of our knowledge of kidney physiology and pathophysiology has been gleaned from a reductionist approach, where careful experimentation has elucidated the effect of one molecular pathway on kidney health and disease, mostly in animal models. However, many kidney diseases, most notably CKD and AKI, comprise diseases of multiple etiologies. Thus, patients enrolled in clinical trials often have heterogeneous disease mechanisms activated, which has likely contributed to the low success rate of clinical trials of pathway-specific targets in nephrology. Biomarkers to further classify subgroups of patients, thus far, have focused more on clinical features rather than on molecular mechanisms that might indicate efficacy of putative therapies. Integrating a wide spectrum of information on the underlying disease mechanism using a systems biology approach has the potential to addresses some of these challenges. This strategy leverages our existing granular knowledge obtained through traditional reductionist approaches toward a holistic understanding of disease processes in a given patient.

A global, or systems biology, approach takes advantage of recent developments in computational methods to integrate diverse types of data, such as molecular, tissue, and clinical parameters, to unravel the interplay of multiple genes, proteins, and molecular mechanisms (Figure 1) that drive discrete steps in kidney health and disease (4,5). A core element of this strategy is the integration of various data sources, including conventional clinical phenotypic patient data, clinicopathologic parameters, and comprehensive genome-scale data sets (also referred to as “omics”) through bio-informatics analytical workflows. Integrating such diverse data into analytical processes necessitate the blending of a variety of expertise including clinical, biologic, information technology, mathematical, statistical, and computational research in nephrology research teams. Sophisticated information technology infrastructure is required to manage and connect information across research and health care. Meanwhile, software tools for analysis and interpretation of data need “integrative workflows” that involve a combination of statistical, computational, and mathematical techniques (6,7). The purpose of this review is to provide an overview of the current state in the evolution of systems biology for the nephrologist. By highlighting the advances made through this approach toward developing targeted therapies linked to mechanistic biomarkers, the potential effect on clinical care and improving outcomes for patients with kidney diseases are discussed (8–⇓10).

Did you find apk for android? You can find new and apps.

What Will You Get?

We provide professional writing services to help you score straight A’s by submitting custom written assignments that mirror your guidelines.

Premium Quality

Get result-oriented writing and never worry about grades anymore. We follow the highest quality standards to make sure that you get perfect assignments.

Experienced Writers

Our writers have experience in dealing with papers of every educational level. You can surely rely on the expertise of our qualified professionals.

On-Time Delivery

Your deadline is our threshold for success and we take it very seriously. We make sure you receive your papers before your predefined time.

24/7 Customer Support

Someone from our customer support team is always here to respond to your questions. So, hit us up if you have got any ambiguity or concern.

Complete Confidentiality

Sit back and relax while we help you out with writing your papers. We have an ultimate policy for keeping your personal and order-related details a secret.

Authentic Sources

We assure you that your document will be thoroughly checked for plagiarism and grammatical errors as we use highly authentic and licit sources.

Moneyback Guarantee

Still reluctant about placing an order? Our 100% Moneyback Guarantee backs you up on rare occasions where you aren’t satisfied with the writing.

Order Tracking

You don’t have to wait for an update for hours; you can track the progress of your order any time you want. We share the status after each step.

image

Areas of Expertise

Although you can leverage our expertise for any writing task, we have a knack for creating flawless papers for the following document types.

Areas of Expertise

Although you can leverage our expertise for any writing task, we have a knack for creating flawless papers for the following document types.

image

Trusted Partner of 9650+ Students for Writing

From brainstorming your paper's outline to perfecting its grammar, we perform every step carefully to make your paper worthy of A grade.

Preferred Writer

Hire your preferred writer anytime. Simply specify if you want your preferred expert to write your paper and we’ll make that happen.

Grammar Check Report

Get an elaborate and authentic grammar check report with your work to have the grammar goodness sealed in your document.

One Page Summary

You can purchase this feature if you want our writers to sum up your paper in the form of a concise and well-articulated summary.

Plagiarism Report

You don’t have to worry about plagiarism anymore. Get a plagiarism report to certify the uniqueness of your work.

Free Features $66FREE

  • Most Qualified Writer $10FREE
  • Plagiarism Scan Report $10FREE
  • Unlimited Revisions $08FREE
  • Paper Formatting $05FREE
  • Cover Page $05FREE
  • Referencing & Bibliography $10FREE
  • Dedicated User Area $08FREE
  • 24/7 Order Tracking $05FREE
  • Periodic Email Alerts $05FREE
image

Our Services

Join us for the best experience while seeking writing assistance in your college life. A good grade is all you need to boost up your academic excellence and we are all about it.

  • On-time Delivery
  • 24/7 Order Tracking
  • Access to Authentic Sources
Academic Writing

We create perfect papers according to the guidelines.

Professional Editing

We seamlessly edit out errors from your papers.

Thorough Proofreading

We thoroughly read your final draft to identify errors.

image

Delegate Your Challenging Writing Tasks to Experienced Professionals

Work with ultimate peace of mind because we ensure that your academic work is our responsibility and your grades are a top concern for us!

Check Out Our Sample Work

Dedication. Quality. Commitment. Punctuality

It May Not Be Much, but It’s Honest Work!

Here is what we have achieved so far. These numbers are evidence that we go the extra mile to make your college journey successful.

0+

Happy Clients

0+

Words Written This Week

0+

Ongoing Orders

0%

Customer Satisfaction Rate
image

Process as Fine as Brewed Coffee

We have the most intuitive and minimalistic process so that you can easily place an order. Just follow a few steps to unlock success.

See How We Helped 9000+ Students Achieve Success

image

We Analyze Your Problem and Offer Customized Writing

We understand your guidelines first before delivering any writing service. You can discuss your writing needs and we will have them evaluated by our dedicated team.

  • Clear elicitation of your requirements.
  • Customized writing as per your needs.

We Mirror Your Guidelines to Deliver Quality Services

We write your papers in a standardized way. We complete your work in such a way that it turns out to be a perfect description of your guidelines.

  • Proactive analysis of your writing.
  • Active communication to understand requirements.
image
image

We Handle Your Writing Tasks to Ensure Excellent Grades

We promise you excellent grades and academic excellence that you always longed for. Our writers stay in touch with you via email.

  • Thorough research and analysis for every order.
  • Deliverance of reliable writing service to improve your grades.
Place an Order Start Chat Now
image