The Glomerulus Filtration Essay

The Glomerulus Filtration Essay

The Glomerulus filtration

Glomerular filtration is the filtration of plasma components (mainly water and a few solutes) into the interstitial spaces of the nephrons via the glomeruli (Saladin, 2020). To determine the amount of glomerular filtration that occurs in the kidneys each minute, scientists utilize a formula that provides a figure that represents the combined rate of both organs.  According to Levey et al. (2020), the glomerular filtration rate is given by the formula; GFR= NFP x Kf = 10 x 12.5 = 125 mL/min.

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The glomerular filtration rate can be controlled by keeping steady blood pressure in the glomeruli. Normal glomerular blood pressure is maintained through the autoregulation of the kidneys, the control of the sympathetic nervous system, and the management of hormones. Nephrons can maintain a steady GFR through a process known as renal autoregulation, which does not rely on external neurological or hormonal control. Levey et al. (2020) depict that during considerable physical activity or when the body is under the effect of other acute stresses, the sympathetic nervous system drives the kidneys to send blood to the heart, brain, skeletal, and muscular systems resulting in GFR control. The hormone known as atrial natriuretic peptide contributes to the hormonal regulation of glomerular filtration, which the kidneys perform. A spike in plasma levels leads the atrial natriuretic peptide to be released, which in turn promotes an increase in the glomerular filtration rate by causing the body to make more urine.

Both hypertension and diabetes are substantial contributors to adult renal failure. If the patient’s diabetes and high blood pressure, both chronic illnesses, are not treated, this might lead to kidney failure. The continuation of an unhealthy lifestyle can potentially result in kidney failure. If these conditions are well managed, there is a decreased likelihood of the patient developing renal failure. Diabetes and high blood pressure, among other illnesses, have been associated with an increased risk of chronic renal disease, which can lead to renal failure if left untreated or neglected.


Levey, A. S., Coresh, J., Tighiouart, H., Greene, T., & Inker, L. A. (2020). Measured and estimated glomerular filtration rate: current status and future directions. Nature Reviews Nephrology, 16(1), 51-64.

Saladin, K. (2020). Anatomy & Physiology: The Unity of Form and Function (9th ed.) [E-book]. McGraw-Hill Education.


What is Glomerular Filtration? How is the Glomerular Filtration Rate (GFR) determined? What regulatory mechanisms help control and stabilize GFR?

Minimum of 2 sources cited (assigned readings/online lessons and an outside source)
APA format for in-text citations and list of references

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