Reading and Analysing A Research Article Exercise 

Reading and Analysing A Research Article Exercise

Article Analysis

Article analysis is an essential aspect of understanding the different parts of the research article. It helps point out the different essential aspects of the research study. This discussion identifies the research problem/hypotheses, purpose statement, study design, participants and how they were selected, the results, whether the hypothesis was rejected or accepted, and the study limitations of a selected article. The selected study is “High-dose vitamin D substitution in patients with COVID-19: study protocol for a randomized, double-blind, placebo-controlled, multi-center study—VitCoy Trial” by Jaun et al. (2022).

The research problem is that there is uncertainty about the direct link between vitamin D deficiency and the severity of Cvid-19, despite evidence supporting an association between vitamin D deficiency and Covid-19 severity. The study’s purpose statement is; to assess whether high-dose vitamin D supplementation has a therapeutic effect in vitamin D-deficient patients with Covid-19.

The study design is a randomized, placebo-controlled, double-blind, multi-center approach was chosen to compare a high single dose of vitamin D (140,000 IU) followed by treatment as usual (TAU) (VitD + TAU) with treatment as usual only (placebo + TAU) in patients with COVID-19 and vitamin D deficiency. The participants were individuals hospitalized in a general medicine ward due to Covid-19. They were selected based on laboratory-confirmed vitamin D deficiency.

The intervention group entails the participants that will receive a single oral dose of 140,000 IU of vitamin D3, then continue with the standard oral dose of 800 IU of vitamin D3 daily until discharge. The control group entails the participants who will receive a single placebo orally and then continue with the standard oral dose of 800 IU of vitamin D3 daily. The outcomes measured are the differences between the TAU+VitD and TAU+placebo in terms of ICU stay, overall mortality, vitamin D serum concentration, laboratory parameters, sepsis, complications, vital signs, and quality of life. The article does not have the results since it is a study protocol/trial that will be implemented later.

Finally, the study limitations include travel regulations and other policies which may be unpredictable, following the unpredictable situations of Covid-19, limiting access to patients. Additionally, due to public health policies, the study implementation may be limited by reducing the number of hospitalized patients.      

References

Jaun, F., Boesing, M., Lüthi-Corridori, G., Abig, K., Makhdoomi, A., Bloch, N., Lins, C., Raess, A., Grillmayr, V., Haas, P., Schuetz, P., Gabutti, L., Muser, J., Leuppi-Taegtmeyer, A. B., Giezendanner, S., Brändle, M., & Leuppi, J. D. (2022). Trials, 23(1), 1–11 https://doi.org/10.1186/s13063-022-06016-2

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Instructions:

Go to the MDC database CINAHL (exercise your knowledge of searching) and search the following article (A copy is also provided below):

Jaun, F., Boesing, M., Lüthi-Corridori, G., Abig, K., Makhdoomi, A., Bloch, N., Lins, C., Raess, A., Grillmayr, V., Haas, P., Schuetz, P., Gabutti, L., Muser, J., Leuppi-Taegtmeyer, A. B., Giezendanner, S., Brändle, M., & Leuppi, J. D. (2022). High-dose vitamin D substitution in patients with COVID-19: study protocol for a randomized, double-blind, placebo-controlled, multi-center study-VitCov Trial.Links to an external site. Trials, 23(1), 1–11.

High-dose vitamin D substitution.pdf Download High-dose vitamin D substitution.pdf

Remember, there are Original research articles that are based on an experiment or study. Often they follow the IMRAD format: introduction, methods, results, and discussion, and Review articles (literature reviews) are written to bring together and summarize the results/conclusions from multiple original research articles/studies. This analysis will be performed in a research study, you may copy and paste the responses.

Find the Research Problem/Hypotheses: Often authors will refer to the purpose of the study. This is often articulated in the abstract, introduction, or background.

Find the purpose statement?

Find the study design?

Identify the participants. How were these chosen?

Identify the control group.

Identify the intervention?

outcomes (what was measured).

What were the results?

Where are the hypotheses rejected or accepted?

Limitations