NUR 550 Topic 1 DQ 1 & 2 Discussion

NUR 550 Topic 1 DQ 1 & 2 Discussion

NUR 550 Topic 1 DQ 1 & 2 Discussion

Topic 1 DQ 1

Assessment Description

Identify the different levels of translational research. Explain how translational research is different from evidence-based practice and discuss application to population health management.

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Topic 1 DQ 2

Assessment Description

Using the GCU Library (notably the “Nursing and Health Sciences Research Guide,” located in the Topic 1 Resources), find a database, journal, or other collection of resources that focuses on translational research. Select a population health problem or issue of interest from the available studies. What type of translational research is used for the study? Provide rationale as to why this is the best.

Resources

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Advanced Practice Nursing: Essential Knowledge for the Profession

Read Chapters 18-21 in Advanced Practice Nursing: Essential Knowledge for the Profession.

View Resource

Evidence-Based Practice in Nursing and Healthcare

Read Chapters 1-3 in Evidence-Based Practice in Nursing and Healthcare.

View Resource

World Health Organization (WHO)

Explore the World Health Organization (WHO) website.

http://who.int/en/

Centers for Disease Control and Prevention (CDC)

Explore the Centers for Disease Control and Prevention (CDC) website.

http://www.cdc.gov/

State and County Departments of Health

Explore the websites of your state and county departments of health and access mortality and morbidity data. The link to the Arizona Depa

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http://www.azdhs.gov/

NCD Burden of Disease

Read “NCD Burden of Disease,” by the U.S. Department of Health and Human Services (HHS), located on the Centers for Disease Contr

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https://www.cdc.gov/globalhealth/healthprotection/fetp/training_modules/2/ncd-burden-of-disease_ppt_final_09252013.pdf

GCU Library Nursing and Health Sciences Research Guide

Refer to the “Nursing and Health Sciences” Research Guide, located on the GCU Library website, for library resources and informat

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https://libguides.gcu.edu/Nursing

The Electronic Health Record: A Friend or Foe of Translational Research and Evidence-Based Practice?

Read “The Electronic Health Record: A Friend or Foe of Translational Research and Evidence-Based Practice?” by Chipps, Tucker, Ga

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https://lopes.idm.oclc.org/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=cul&AN=137966885&site=ehost-live&scope=site&custid=s8333196&groupid=main&profile=ehost

Evidence-Based Practice

Read “Evidence-Based Practice” by Melnyk and Fineout-Overholt, from Encyclopedia of Nursing Research (2017), located in

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https://lopes.idm.oclc.org/login?url=https://search.credoreference.com/content/entry/spennurres/evidence_based_practice/0?institutionId=5865

Translation Research in Practice: An Introduction

Read “Translation Research in Practice: An Introduction,” by Titler, from Online Journal of Issues in Nursing (2018).

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https://lopes.idm.oclc.org/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=cul&AN=130158156&site=ehost-live&scope=site&custid=s8333196&groupid=main&profile=ehost

PICO, PICOTS, PICOTT Framework for Clinical Questions as a Way to Design Clinical Trials

Read “PICO, PICOTS, PICOTT Framework for Clinical Questions as a Way to Design Clinical Trials,” by Deng (2020), located on the&#

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http://onbiostatistics.blo

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Topic 1 DQ 1: Levels of Translational Research

Translational research is the foundation of improved health outcomes for patients and communities. Zarbin (2020) classified translational research into T1, T2, T3, and T4 phases, with each contributing differently to the advancement of clinical knowledge and the availability of scientific evidence to improve health outcomes. T1 (translation to humans) involves developing new concepts and discoveries from basic research through early-phase clinical trials. Basic research (T0) is primarily about preclinical and animal studies, which leads to new knowledge (Molloy & Bearer, 2021). T2 (translation to patients) involves controlled studies designed to improve clinical effectiveness. Suitable examples include phase 2 and 3 clinical trials. T3 (translation to practice) involves phase 4 clinical trials as a foundation for delivering recommended and timely care to the right patient (Molloy & Bearer, 2021). T4 (translation to community) involves population-level outcome research. It concentrates on assessing outcomes and the appropriateness of clinical interventions in populations. Generally, these classifications denote a steady progression of investigative activities seeking to provide scientific capital.

As innovators and change agents, nursing professionals should understand the difference between translational research and evidence-based practice (EBP). As Molloy and Bearer (2021) noted, translation is primarily about turning laboratory, clinical, and community observations into interventions that improve individuals and public health. These interventions include diagnostics, behavioral changes, and medical procedures. On the other hand, EBP involves integrating the best available evidence with clinical expertise and patient values to improve patient care (White et al., 2021). In this case, EBP implements the available scientific evidence. Translational research is valuable in population health management since it is the source of knowledge for timely and effective care (Zarbin, 2020). Implementing this knowledge improves health outcomes, hence creating safer, healthier, and more productive populations. T4 focuses on research that benefits communities. It is centered on translating new data into health decision-making, which ensures there are adequate processes, technologies, and other interventions that could be implemented to improve population health.

References

Molloy, E. J., & Bearer, C. F. (2021). Translational research is all-encompassing and lets everyone be a researcher. Pediatric Research, 90(1), 2-3. https://doi.org/10.1038/s41390-020-01225-4

White, J., Grant, K., Sarkies, M., Haines, T., & Evidence Translation in Allied Health (EviTAH) Group Meg E. Morris Leeanne Carey Nicholas F. Taylor Anne E. Holland Anne Bardoel Cylie Williams Lisa O’Brien Elizabeth H. Skinner Jenny Martin. (2021). Translating evidence into practice: a longitudinal qualitative exploration of allied health decision-making. Health Research Policy and Systems, 19, 1-11. https://doi.org/10.1186/s12961-020-00662-1

Zarbin, M. (2020). What constitutes translational research? Implications for the scope of translational vision science and technology. Translational Vision Science & Technology, 9(8), 22-22. https://doi.org/10.1167%2Ftvst.9.8.22

Topic 1 DQ 2: Translational Research in Studies

Healthcare professionals and researchers keep on advancing health interventions through new methods, tools, and knowledge. Translational research helps to address population health problems by facilitating the movement of knowledge from research into diagnosis or treatment (Strand, 2020). This knowledge is also the foundation of evidence-based protocols as care providers deploy it in clinical practice to benefit individuals and society. A recent population health problem necessitating translational research and scientific advancements is the COVID-19 pandemic. Bahsoun et al. (2023) described the pandemic as a significant public health burden that crippled the global healthcare system and associated with high infection rates and mortality. As a result, research is crucial to guide nursing professionals on effective diagnosis, treatment, and prevention to prevent and manage infections.

COVID-19 treatment via steroids is extensively studied to produce new knowledge for clinical practice. Lin et al. (2021) explored the role of steroids in COVID-19 management guided by the principle that corticosteroids are effective in managing pulmonary disorders due to the inhibition of the inflammatory cascade. In this article, the authors point out that managing COVID-19-infected patients through corticosteroids produces desirable effects since the treatment targets the host immune response and inflammatory cascade. Concerning the type of translational research, the study falls under T1 (translation to humans) since it is on new methods of treatment and illness prevention (Molloy & Bearer, 2021). Often, healthcare professionals and the general public encounter new health concerns, such as pandemics, with significant impacts due to their high infection and mortality rates. T1 research is the best to ensure clinicians are effectively guided in diagnosing, treating, and preventing such public health problems. The COVID-19 pandemic requires such an approach, and new knowledge on the appropriateness of various treatments is crucial to ensure effective control and prevention.

References

Bahsoun, A., Fakih, Y., Zareef, R., Bitar, F., & Arabi, M. (2023). Corticosteroids in COVID-19: pros and cons. Frontiers in Medicine, 10, 1202504. https://doi.org/10.3389/fmed.2023.1202504

Lin, Z., Phyu, W. H., Phyu, Z. H., Mon, T. Z., & Mon, T. Z. (2021). The role of steroids in the management of COVID-19 infection. Cureus, 13(8): e16841. doi:10.7759/cureus.16841

Molloy, E. J., & Bearer, C. F. (2021). Translational research is all-encompassing and lets everyone be a researcher. Pediatric Research, 90(1), 2-3. https://doi.org/10.1038/s41390-020-01225-4

Strand, D. L. (2020). Everyday characterizations of translational research: researchers’ own use of terminology and models in medical research and practice. Palgrave Communications, 6(1), 1-10. https://doi.org/10.1057/s41599-020-0489-1